PREZCOBIX (darunavir and cobicistat) tablets, for oral use. Initial U.S. Approval – 2015

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PREZCOBIX (darunavir and cobicistat) tablets, for oral use. Initial U.S. Approval – 2015

INDICATIONS AND USAGE
PREZCOBIX is a two drug combination of darunavir, a human immunodeficiency virus (HIV-1) protease inhibitor and cobicistat, a CYP3A inhibitor and is indicated for the treatment of HIV-1 infection in adultpatients.
DOSAGE FORMS & STRENGTHS
Tablets: 800 mg of darunavir and 150 mg of cobicistat.
Manufactured By: Janssen Products, LP
Prescribing Information URL: Click Here

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A current focus in HIV management is improving adherence by minimizing pill burden with convenient formulations, including fixed-dose combinations (FDCs). Darunavir, a HIV protease inhibitor, co-administered with low-dose ritonavir (800/100 mg once daily), is recommended in guidelines in combination with other antiretrovirals for HIV patients with no darunavir resistance-associated mutations. Cobicistat is an alternative agent to ritonavir for boosting plasma drug levels of darunavir among other antiretrovirals. Cobicistat is a more specific cytochrome P450 3A inhibitor than ritonavir without enzyme-inducing properties.

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